anti-hyperglycemic effect of chebulagic acid from the fruits of terminalia chebula retzanti-hyperglycemic chebulagic酸效果的水果榄仁树属chebula retz.pdfVIP

Int. J. Mol. Sci. 2012, 13, 6320-6333; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Anti-Hyperglycemic Effect of Chebulagic Acid from the Fruits of Terminalia chebula Retz Yi-Na Huang 1,†, Dong-Dong Zhao 2,†, Bo Gao 1,†, Kai Zhong 3,†, Rui-Xue Zhu 3, Yan Zhang 3, Wang-Jun Xie 3, Li-Rong Jia 3,* and Hong Gao 3,* 1 Department of Public Health, Hua Xi Medicinal Center of Sichuan University, Chengdu 610041, China; E-Mails: dir0932@ (Y.-N.H.); gaobo03@ (B.G.) 2 Sichuan Academy of Medical Science Sichuan Provincial People’s Hospital, Chengdu 610072, China; E-Mail: zhaodongd@ 3 College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu 610065, China; E-Mails: eric211@163.com (K.Z.); zhu_ruixue@126.com (R.-X.Z.); yanzhang-scu@ (Y.Z.); gaobingchuang@ (W.-J.X.) † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: jialirong@ (L. -R.J.); gao523@ (H.G.); Tel.: +86-28-8540-5236; Fax: +86-28-8540-5137. Received: 1 April 2012; in revised form: 14 May 2012 / Accepted: 16 May 2012 / Published: 22 May 2012 Abstract: In the present study, we firstly compared rat intestinal α-glucosidase inhibitory activity by different ethanol-aqueous extractions from the dried fruits of Terminalia chebula Retz. The enzymatic assay showed that the 80% ethanol extract was more potent against maltase activit