有哪些信誉好的足球投注网站anti-angiogenic and anti-inflammatory effects of serpina3k on corneal injury抗血管生成和抗炎serpina3k对角膜损伤的影响.pdfVIP
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anti-angiogenic and anti-inflammatory effects of serpina3k on corneal injury抗血管生成和抗炎serpina3k对角膜损伤的影响
Anti-Angiogenic and Anti-Inflammatory Effects of
SERPINA3K on Corneal Injury
1. 1. 1 1 1 1 2
Xiaochen Liu , Zhirong Lin , Tong Zhou , Ronrong Zong , Hui He , Zhen Liu , Jian-xing Ma , Zuguo
1 1
Liu *, Yueping Zhou *
1 Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China, 2 Department of Physiology, The University of
Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
Abstract
SERPINA3K is a member of the serine proteinase inhibitor (SERPIN) family. Here we evaluated the therapeutic effects of
SERPINA3K on neovascularization and inflammation in a rat cornea alkali burn model that is commonly employed to study
corneal wounding. Topical treatment of the injured rat cornea with SERPINA3K (20 mg/eye/day) for 7 days significantly
decreased the neovascular area, compared with the groups treated with BSA or PBS. The SERPINA3K treatment also
ameliorated the corneal inflammation as evaluated by the inflammatory index. Furthermore, SERPINA3K enhanced the
recovery of corneal epithelium after the alkali injury. Toward the mechanism of action, SERPINA3K down-regulated the
expression of the pro-angiogenic and pro-inflammatory factors, vascular endothelial growth factor and tumor necrosis
factor-a and up-regulated the expression of the anti-angiogenic factor, pigment epithelium-derived factor. SERPINA3K
specifically inhibited growth of vascular endothelial cells. Meanwhile, SERPINA3K significantly up-regulated the expression
of EGFR in the corneal epithelium. These findings suggest that SERPINA3K has the
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