有哪些信誉好的足球投注网站anthrax toxin receptor 2 functions in ecm homeostasis of the murine reproductive tract and promotes mmp activity炭疽毒素受体2 ecm内稳态的小鼠生殖系统功能,促进mmp的活动.pdfVIP
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anthrax toxin receptor 2 functions in ecm homeostasis of the murine reproductive tract and promotes mmp activity炭疽毒素受体2 ecm内稳态的小鼠生殖系统功能,促进mmp的活动
Anthrax Toxin Receptor 2 Functions in ECM Homeostasis
of the Murine Reproductive Tract and Promotes MMP
Activity
1 1 2 1 1
Claire V. Reeves , Xing Wang , Pelisa C. Charles-Horvath , Joy Y. Vink , Valeriya Y. Borisenko ,
John A. T. Young3, Jan K. Kitajewski1,4,5*
1 Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York, United States of America, 2 Department of Pharmacology,
Columbia University Medical Center, New York, New York, United States of America, 3 Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for
Biological Studies, La Jolla, California, United States of America, 4 Department of Pathology, Columbia University Medical Center, New York, New York, United States of
America, 5 Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, United States of America
Abstract
Anthrax Toxin Receptor proteins function as receptors for anthrax toxin, however physiological activity remains unclear. To
evaluate the biological role of Antxr2, we generated Antxr2 2/ 2 mice. Antxr2 2/ 2 mice were viable, however Antxr2 is
required for parturition in young females and for preserving fertility in older female mice. Histological analysis of the uterus
and cervix revealed aberrant deposition of extracellular matrix proteins such as type I collagen, type VI collagen and
fibronectin. A marked disruption of both the circular and longitudinal myometrial cell layers was evident in Antxr2 2/ 2 mice.
These changes progressed as the mice aged, resulting in a thickened, collagen dense, acellular stroma and the
disappearance of normal uterine architecture. To investigate the molecular mechanism u
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