antibacterial secondary metabolites from the cave sponge xestospongia sp.从洞穴海绵xestospongia sp抗菌次生代谢物。.pdfVIP

Mar. Drugs 2012, 10, 1037-1043; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Antibacterial Secondary Metabolites from the Cave Sponge Xestospongia sp. Sridevi Ankisetty and Marc Slattery Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; E-Mails: ankisett@ (S.A.); slattery@ (M.S.); Tel.: +1-662-915-1706 (S.A.); +1-662-915- 1053 (M.S.); Fax: +1-662-915-6975 (S.A.) Received: 5 March 2012; in revised form: 24 April 2012 / Accepted: 1 May 2012 / Published: 7 May 2012 Abstract: Chemical investigation of the cave sponge Xestospongia sp. resulted in the isolation of three new polyacetylenic long chain compounds along with two known metabolites. The structures of the new metabolites were established by NMR and MS analyses. The antibacterial activity of the new metabolites was also evaluated. Keywords: Xestospongia ; polyacetylenes; antibacterial activity 1. Introduction Sponges of the genera Haliclona, Adocia , Xestospongia , Strongylophora, Petrosia belonging to the order Haplosclerida have been rich sources of long-chain polyacetylenic alcohols which can be considered as chemotaxonomic markers [1] and these represent a rapidly growing class of sponge metabolites. Common hydroxylated polyacetylenes and brominated C18 acetylenic acids are the major class of metabolites reported from the above genera. Polyacetylenes have been found to sho