有哪些信誉好的足球投注网站anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model抗风湿自由基清除的影响在人类白介素1β-stimulated呈synoviocytes和在大鼠关节炎模型.pdfVIP
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anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model抗风湿自由基清除的影响在人类白介素1β-stimulated呈synoviocytes和在大鼠关节炎模型
Anti-Arthritic Effects of Magnolol in Human Interleukin
1b-Stimulated Fibroblast-Like Synoviocytes and in a Rat
Arthritis Model
1 2 3 1 4
Jyh-Horng Wang , Kao-Shang Shih , Jing-Ping Liou , Yi-Wen Wu , Anita Shin-Yuan Chang , Kang-Li
4 1 4
Wang , Ching-Lin Tsai , Chia-Ron Yang *
1 Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei, Taiwan, 2 Orthopedic Department, Shin Kong Wu Ho-Su Memorial Hospital, Taipei,
Taiwan, 3 School of Pharmacy, Taipei Medical University, Taipei, Taiwan, 4 School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
Abstract
Fibroblast-like synoviocytes (FLS) play an important role in the pathologic processes of destructive arthritis by producing a
number of catabolic cytokines and metalloproteinases (MMPs). The expression of these mediators is controlled at the
transcriptional level. The purposes of this study were to evaluate the anti-arthritic effects of magnolol (5,59-Diallyl-biphenyl-
2,29-diol), the major bioactive component of the bark of Magnolia officinalis, by examining its inhibitory effects on
inflammatory mediator secretion and the NF-kB and AP-1 activation pathways and to investigate its therapeutic effects on
the development of arthritis in a rat model. The in vitro anti-arthritic activity of magnolol was tested on interleukin (IL)-1b-
stimulated FLS by measuring levels of IL-6, cyclooxygenase-2, prostaglandin E2, and matrix metalloproteinases (MMPs) by
ELISA and RT-PCR. Further studies on how magnolol inhibits IL-1b-stimulated cytokine expression were performed using
Western blots, reporter gene assay, electrophoretic mobility shift assay, and confoca
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