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an irgd based strategy to study electrochemically the species inside a cell基于irgd策略研究电化学物种在一个细胞
Int. J. Mol. Sci. 2012, 13, 10424-10431; doi:10.3390/ijms130810424
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
An iRGD Based Strategy to Study Electrochemically the Species
Inside a Cell
Limin Ning 1, Xiaoxi Li 1, Xiaorong Ding 2,3, Yongmei Yin 3 and Genxi Li 1,2,*
1 Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology,
Nanjing University, Nanjing 210093, China; E-Mails: ninglimin2006@126.com (L.N.);
lxx.zlxhaoyou@ (X.L.)
2 Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University,
Shanghai 200444, China; E-Mail: dingxiaoronglaofuzi@126.com
3 Department of Oncology, the First Affiliated Hospital of Nanjing Medical University,
Nanjing 210029, China; E-Mail:ym.yin@
* Author to whom correspondence should be addressed; E-Mail: genxili@;
Tel.: +86-25-8359-3596; Fax: +86-25-8359-2510.
Received: 15 May 2012; in revised form: 27 June 2012 / Accepted: 9 August 2012 /
Published: 21 August 2012
Abstract: This paper reports a method for electrical communication between the inner part
of cells and an electrode with the help of iRGD peptide. Due to the enhancement of the cell
penetration caused by iRGD peptide, DNA molecules, previously modified on a gold
electrode surface, can be easily transfected into the cells. At the same time, doxorubicin, an
anticancer drug, can also be transfected into cells with high penetra
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