an ileal crohns disease gene signature based on whole human genome expression profiles of disease unaffected ileal mucosal biopsies一个回肠克罗恩病基因签名基于整个人类基因组表达谱的疾病影响回肠粘膜活检.pdfVIP

An Ileal Crohn’s Disease Gene Signature Based on Whole Human Genome Expression Profiles of Disease Unaffected Ileal Mucosal Biopsies 1 1 1 2 3 3 Tianyi Zhang , Bowen Song , Wei Zhu , Xiao Xu , Qing Qing Gong , Christopher Morando , 3 3 4 2,3 Themistocles Dassopoulos , Rodney D. Newberry , Steven R. Hunt , Ellen Li * 1 Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, United States of America, 2 Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America, 3 Department of Medicine, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America, 4 Department of Surgery, Washington University-St. Louis School of Medicine, Saint Louis, Missouri, United States of America Abstract Previous genome-wide expression studies have highlighted distinct gene expression patterns in inflammatory bowel disease (IBD) compared to control samples, but the interpretation of these studies has been limited by sample heterogeneity with respect to disease phenotype, disease activity, and anatomic sites. To further improve molecular classification of inflammatory bowel disease phenotypes we focused on a single anatomic site, the disease unaffected proximal ileal margin of resected ileum, and three phenotypes that were unlikely to overlap: ileal Crohn’s disease (ileal CD), ulcerative colitis (UC), and control patients without IBD. Whole huma