有哪些信誉好的足球投注网站altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats改变叫醌营养状况调节线粒体脂质,和老鼠体内能量代谢.pdfVIP
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altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats改变叫醌营养状况调节线粒体脂质,和老鼠体内能量代谢
Altering Pyrroloquinoline Quinone Nutritional Status
Modulates Mitochondrial, Lipid, and Energy Metabolism
in Rats
1 1 1 1,2 1,2
Kathryn Bauerly , Calliandra Harris , Winyoo Chowanadisai , James Graham , Peter J. Havel ,
3 1 4 1,4
Eskouhie Tchaparian , Mike Satre , Joel S. Karliner , Robert B. Rucker *
1 Nutrition, University of California Davis, Davis, California, United States of America, 2 Molecular Biosciences, Veterinary Medicine, University of California Davis, Davis,
California, United States of America, 3 Amgen Inc., South San Francisco, California, United States of America, 4 Cardiology, VA Medical Center, San Francisco, California,
United States of America
Abstract
We have reported that pyrroloquinoline quinone (PQQ) improves reproduction, neonatal development, and mitochondrial
function in animals by mechanisms that involve mitochondrial related cell signaling pathways. To extend these
observations, the influence of PQQ on energy and lipid relationships and apparent protection against ischemia reperfusion
injury are described herein. Sprague-Dawley rats were fed a nutritionally complete diet with PQQ added at either 0 (PQQ2)
or 2 mg PQQ/Kg diet (PQQ+). Measurements included: 1) serum glucose and insulin, 2) total energy expenditure per
metabolic body size (Wt3/4), 3) respiratory quotients (in the fed and fasted states), 4) changes in plasma lipids, 5) the relative
mitochondrial amount in liver and heart, and 6) indices related to cardiac ischemia. For the latter, rats (PQQ2 or PQQ+) were
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