adrenal steroids uniquely influence sexual motivation behavior in male rats肾上腺类固醇独特影响雄性小鼠的性动机的行为.pdfVIP

Behav. Sci. 2012, 2, 195-206; doi:10.3390/bs2030195 OPEN ACCESS Behavioral Sciences ISSN 2076-328X /journal/behavsci/ Article Adrenal Steroids Uniquely Influence Sexual Motivation Behavior in Male Rats George T. Taylor 1, Joshua T. Dearborn 1,2,* and Susan E. Maloney 1,2 1 Behavioral Neuroscience Group, University of Missouri-St. Louis, 8001 Natural Bridge Road, St. Louis, MO 63110, USA; E-Mails: geot@ (G.T.T.); sem885@ (S.E.M.) 2 Department of Psychiatry, School of Medicine, Washington University in St. Louis, Box 8134, 660 S. Euclid, St. Louis, MO 63110, USA * Author to whom correspondence should be addressed; E-Mail: jtdmrb@ ; Tel./Fax: +1-314-362-7723. Received: 4 July 2012; in revised form: 11 August 2012 / Accepted: 21 August 2012 / Published: 31 August 2012 Abstract: The androgenic adrenal steroids dehydroepiandrosterone (DHEA) and 4α-androstenedione (4-A) have significant biological activity, but it is unclear if the behavioral effects are unique or only reflections of the effects of testosterone (TS). Gonadally intact male Long-Evans rats were assigned to groups to receive supplements of DHEA, 4-A, TS, corticosteroid (CORT), all at 400 µg steroid/kg of body weight, or vehicle only for 5 weeks. All males were tested in a paradigm for sexual motivation that measures time and urinary marks near an inaccessible receptive female. It was found that DHEA and 4-A supplements failed to i