有哪些信誉好的足球投注网站altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen vi null mice改变骨小梁结构和延迟的膝盖软骨变性胶原vi零老鼠.pdfVIP
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altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen vi null mice改变骨小梁结构和延迟的膝盖软骨变性胶原vi零老鼠
Altered Trabecular Bone Structure and Delayed Cartilage
Degeneration in the Knees of Collagen VI Null Mice
1,2 3 1 1 1
Susan E. Christensen , Jeffrey M. Coles , Nicole A. Zelenski , Bridgette D. Furman , Holly A. Leddy ,
3 4 1,2,3
Stefan Zauscher , Paolo Bonaldo , Farshid Guilak *
1 Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, United States of America, 2 Department of Biomedical Engineering, Duke
University, Durham, North Carolina, United States of America, 3 Department of Mechanical Engineering Materials Science, Duke University, Durham, North Carolina,
United States of America, 4 Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
Abstract
Mutation or loss of collagen VI has been linked to a variety of musculoskeletal abnormalities, particularly muscular
dystrophies, tissue ossification and/or fibrosis, and hip osteoarthritis. However, the role of collagen VI in bone and cartilage
structure and function in the knee is unknown. In this study, we examined the role of collagen VI in the morphology and
physical properties of bone and cartilage in the knee joint of Col6a12/ 2 mice by micro-computed tomography (microCT),
histology, atomic force microscopy (AFM), and scanning microphotolysis (SCAMP). Col6a12/ 2 mice showed significant
differences in trabecular bone structure, with lower bone volume, connectivity density, trabecular number, and trabecular
thickness but higher structure model index and trabecular separation compared to Col6a1+/+ mi
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