altered neural and behavioral dynamics in huntingtons disease an entropy conservation approach改变了神经和行为动力学在亨廷顿氏舞蹈症熵守恒的方法.pdfVIP

Altered Neural and Behavioral Dynamics in Huntington’s Disease: An Entropy Conservation Approach 1 2 2 S. Lee Hong , Scott J. Barton , George V. Rebec * 1 Department of Kinesiology, Indiana University, Bloomington, Indiana, United States of America, 2 Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America Abstract Background: Huntington’s disease (HD) is an inherited condition that results in neurodegeneration of the striatum, the forebrain structure that processes cortical information for behavioral output. In the R6/2 transgenic mouse model of HD, striatal neurons exhibit aberrant firing patterns that are coupled with reduced flexibility in the motor system. The aim of this study was to test the patterns of unpredictability in brain and behavior in wild-type (WT) and R6/2 mice. Methodology/Principal Findings: Striatal local field potentials (LFP) were recorded from 18 WT and 17 R6/2 mice (aged 8– 11 weeks) while the mice were exploring a plus-shaped maze. We targeted LFP activity for up to 2 s before and 2 s after each choice-point entry. Approximate Entropy (ApEn) was calculated for LFPs and Shannon Entropy was used to measure the probability of arm choice, as well as the likelihood of making consecutive 90-degree turns in the maze. We found that although the total number of choice-point crossings and entropy of arm-choice probability was similar in both groups, R6/2 mice had more predictable behavioral responses (i.e., were less likely to make 90-degree turns and perform them in alternation with running straight down the same arm), while exhibiting more unpredictable striatal activity, as indicated by higher ApEn values. In both WT and R6/2 mice, however, behavioral unpredictability was negatively correlated with LF