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altered metabolic signature in pre-diabetic nod mice改变代谢签名前驱糖尿病老鼠点头
Altered Metabolic Signature in Pre-Diabetic NOD Mice
1 2 3 1 2
Rasmus Madsen , Viqar Showkat Banday , Thomas Moritz , Johan Trygg , Kristina Lejon *
˚ ˚
1 Computational Life Science Cluster (CLiC), Department of Chemistry, Umea University, Umea, Sweden, 2 Division of Immunology, Department of Clinical Microbiology,
˚ ˚ ˚ ˚
Umea University, Umea, Sweden, 3 Umea Plant Science Center, Department of Forest Genetics and Plant Physiology, Swedish University of Agriculture Sciences, Umea,
Sweden
Abstract
Altered metabolism proceeding seroconversion in children progressing to Type 1 diabetes has previously been
demonstrated. We tested the hypothesis that non-obese diabetic (NOD) mice show a similarly altered metabolic profile
compared to C57BL/6 mice. Blood samples from NOD and C57BL/6 female mice was collected at 0, 1, 2, 3, 4, 5, 6, 7, 9, 11, 13
and 15 weeks and the metabolite content was analyzed using GC-MS. Based on the data of 89 identified metabolites OPLS-
DA analysis was employed to determine the most discriminative metabolites. In silico analysis of potential involved
metabolic enzymes was performed using the dbSNP data base. Already at 0 weeks NOD mice displayed a unique metabolic
signature compared to C57BL/6. A shift in the metabolism was observed for both strains the first weeks of life, a pattern that
stabilized after 5 weeks of age. Multivariate analysis revealed the most discriminative metabolites, which in
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