有哪些信誉好的足球投注网站alphavirus replicon particles expressing trp-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity甲病毒复制子粒子表达trp-2提供强有力的治疗效果在黑色素瘤通过激活体液和细胞免疫.pdfVIP
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Alphavirus Replicon Particles Expressing TRP-2 Provide
Potent Therapeutic Effect on Melanoma through
Activation of Humoral and Cellular Immunity
1 1 2 1
Francesca Avogadri , Taha Merghoub , Maureen F. Maughan , Daniel Hirschhorn-Cymerman ,
2 3 2 1 1,3
John Morris , Erika Ritter , Robert Olmsted , Alan N. Houghton , Jedd D. Wolchok *
1 Swim Across America Laboratory, Immunology Program, Sloan-Kettering Institute, New York, New York, United States of America, 2 AlphaVax, Inc., Research Triangle
Park, North Carolina, United States of America, 3 Ludwig Institute for Cancer Research, New York Branch, New York, New York, United States of America
Abstract
Background: Malignant melanoma is the deadliest form of skin cancer and is refractory to conventional chemotherapy and
radiotherapy. Therefore alternative approaches to treat this disease, such as immunotherapy, are needed. Melanoma
vaccine design has mainly focused on targeting CD8+ T cells. Activation of effector CD8+ T cells has been achieved in
patients, but provided limited clinical benefit, due to immune-escape mechanisms established by advanced tumors. We
have previously shown that alphavirus-based virus-like replicon particles (VRP) simultaneously activate strong cellular and
humoral immunity against the weakly immunogenic melanoma differentiation antigen (MDA) tyrosinase. Here we further
investigate the antitumor effect and the immune mechanisms of VRP encoding different MDAs.
Methodology/Principal Findings: VRP encoding different MDAs were screened for their ability to prevent the growth of the
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