adaptive evolution of leptin in heterothermic bats自适应进化的瘦素heterothermic蝙蝠.pdfVIP

Adaptive Evolution of Leptin in Heterothermic Bats 1,2 3 1 4 5 5 Lihong Yuan , Xudong Zhao , Benfu Lin , Stephen J. Rossiter , Lingjiang He , Xueguo Zuo , Guimei 5 6 7 5 He , Gareth Jones , Fritz Geiser , Shuyi Zhang * 1 South China Institute of Endangered Animals, Guangzhou, China, 2 Key Laboratory of Marine Bio-resources Sustainable Utilization, Key Laboratory of Applied Marine Biology of Guangdong Province, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China, 3 Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 4 School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom, 5 Institute of Molecular Ecology and Evolution, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, China, 6 School of Biological Sciences, University of Bristol, Bristol, United Kingdom, 7 Center for Behavioural and Physiological Ecology, Zoology, University of New England, Armidale, Australia Abstract Heterothermy (hibernation and daily torpor) is a key strategy that animals use to survive in harsh conditions and is widely employed by bats, which are found in diverse habitats and climates. Bats comprise more than 20% of all mammals and although heterothermy occurs in divergent lineages of bats, suggesting it might be an ancestral condition, its evolutionary history is complicated by complex phylogeographic patterns. Here, we use Leptin, which regulates lipid metabolism and is crucial for thermogenesis of hibernators, as molecular marker and combine physiological, molecular and biochemical analyses to explore the possible evolutionary history of heterothermy in bat. The two tropi