alleviation of gut inflammation by cdx2pxr pathway in a mouse model of chemical colitis减轻肠道炎症的化学结肠炎的cdx2pxr途径在小鼠模型.pdfVIP

Alleviation of Gut Inflammation by Cdx2/Pxr Pathway in a Mouse Model of Chemical Colitis 1,2. 1. 1 1 1 Wei Dou , Subhajit Mukherjee , Hao Li , Madhukumar Venkatesh , Hongwei Wang , 3 1 4 2,5 6 7 Sandhya Kortagere , Ariel Peleg , Sridhar S. Chilimuri , Zheng-Tao Wang *, Ying Feng , Eric R. Fearon , Sridhar Mani1* 1 Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, New York, United States of America, 2 Shanghai Key Laboratory of Formulated Chinese Medicines and MOE Key Laboratory for Standardization Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of TCM, Shanghai, China, 3 Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, 4 Department of Medicine, Bronx Lebanon Hospital Center, Bronx, New York, United States of America, 5 Institute of Chinese Materia Medica, Shanghai University of TCM, Shanghai, China, 6 Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, 7 Division of Molecular Medicine and Genetics, Department of Internal Medicine, Human Genetics and Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America Abstract Pregnane X Receptor (PXR), a master regulator of drug metabolism and inflammation, is abundantly expressed in the gastrointestinal tract. Baicalein and its O-glucuronide baicalin are potent anti-inflammatory and anti-cancer herbal flavonoids that un