alcohol consumption, genetic variants in alcohol deydrogenases, and risk of cardiovascular diseases a prospective study and meta-analysis饮酒,酒精deydrogenases基因变异,心血管疾病风险的前瞻性研究和荟萃分析.pdfVIP
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alcohol consumption, genetic variants in alcohol deydrogenases, and risk of cardiovascular diseases a prospective study and meta-analysis饮酒,酒精deydrogenases基因变异,心血管疾病风险的前瞻性研究和荟萃分析
Alcohol Consumption, Genetic Variants in Alcohol
Deydrogenases, and Risk of Cardiovascular Diseases: A
Prospective Study and Meta-Analysis
1 2,5 ¨ 1 ¨ 1 3
Dagmar Drogan *, Abigail J. Sheldrick , Madlen Schutze , Sven Knuppel , Frank Andersohn , Romina
1 1,6 3 4 1
di Giuseppe , Bianca Herrmann , Stefan N. Willich , Edeltraut Garbe , Manuela M. Bergmann , Heiner
Boeing1, Cornelia Weikert1,3
1 Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany, 2 Institute of Clinical Pharmacology and Toxicology;
´ ´
Charite University Medical Center, Berlin, Germany, 3 Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin,
Germany, 4 Department of Clinical Epidemiology, Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany, 5 Department of Psychiatry,
Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany, 6 Department 4.1 Biology in Materials Protection and Environmental
Issues, Federal Institute for Materials Research and Testing, Berlin, Germany
Abstract
Objective: First, to investigate and compare associations between alcohol consumption and variants in alcohol
dehydrogenase (ADH) genes with incidence of cardiovascular diseases (CVD) in a large German cohort. Second, to
quantitatively summarize avail
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