有哪些信誉好的足球投注网站activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells可溶性的激活腺苷酸环化酶防止促分泌素刺激发酵菌激活大鼠pancreaic腺泡的细胞.pdfVIP
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activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells可溶性的激活腺苷酸环化酶防止促分泌素刺激发酵菌激活大鼠pancreaic腺泡的细胞
Activation of Soluble Adenylyl Cyclase Protects against
Secretagogue Stimulated Zymogen Activation in Rat
Pancreaic Acinar Cells
1,3 1,3 1,3 4 4
Thomas R. Kolodecik , Christine A. Shugrue , Edwin C. Thrower , Lonny R. Levin , Jochen Buck ,
Fred S. Gorelick1,2,3*
1 Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, 2 Department of
Cell Biology, Yale University School of Medicine, New Haven, Connecticut, United States of America, 3 Veterans Administration Connecticut Healthcare, West Haven,
Connecticut, United States of America, 4 Department of Pharmacology, Weill Medical College of Cornell University, New York, New York, United States of America
Abstract
An early feature of acute pancreatitis is activation of zymogens, such as trypsinogen, within the pancreatic acinar cell.
Supraphysiologic concentrations of the hormone cholecystokinin (CCK; 100 nM), or its orthologue cerulein (CER), induce
zymogen activation and elevate levels of cAMP in pancreatic acinar cells. The two classes of adenylyl cyclase, trans-
membrane (tmAC) and soluble (sAC), are activated by distinct mechanisms, localize to specific subcellular domains, and can
produce locally high concentrations of cAMP. We hypothesized that sAC activity might selectively modulate acinar cell
zymogen activation. sAC was identified in acinar cells by PCR and immunoblot. It localized to the apical region of the cell
under resting conditions and redistributed intracellularly after treatment with supraphysiologic concentrations of cerulein.
In cerulein-treated cells, pre-incubation with a trans-membrane ad
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