activation of regulatory t cells during inflammatory response is not an exclusive property of stem cells调节性t细胞在炎症反应的激活不是干细胞的独家财产.pdfVIP

Activation of Regulatory T Cells during Inflammatory Response Is Not an Exclusive Property of Stem Cells 1 1 2 3 Jan-Hendrik Gosemann *, Joachim F. Kuebler , Michela Pozzobon , Claudia Neunaber , 1 4 4 1 1 Julia H. K. Hensel , Marco Ghionzoli , Paolo de Coppi , Benno M. Ure , Gesine Holze 1 Center of Pediatric Surgery Hannover, Hannover Medical School and Bult Children’s Hospital, Hannover, Germany, 2 Stem Cell Processing Laboratory, Clinic of Pediatric Oncohematology, University of Padova, Padova, Italy, 3 Trauma Department, Hannover Medical School, Hannover, Germany, 4 Surgery Unit, UCL Institute of Child Health, Great Ormond Street Hospital, London, United Kingdom Abstract Background: Sepsis and systemic-inflammatory-response-syndrome (SIRS) remain major causes for fatalities on intensive care units despite up-to-date therapy. It is well accepted that stem cells have immunomodulatory properties during inflammation and sepsis, including the activation of regulatory T cells and the attenuation of distant organ damage. Evidence from recent work suggests that these properties may not be exclusively attributed to stem cells. This study was designed to evaluate the immunomodulatory potency of cellular treatment during acute inflammation in a model of sublethal endotoxemia and to investigate the hypothesis that immunomodulations by cellular treatment during inflammatory response is not stem cell specific. Methodology/Principal Findings: Endotoxemia was induced via intra-peritoneal injection of lipopolysaccharide (LPS) in wild type mice (C3H/