有哪些信誉好的足球投注网站alanine zipper-like coiled-coil domains are necessary for homotypic dimerization of plant gaga-factors in the nucleus and nucleolus丙氨酸zipper-like卷曲螺旋域所需的同型的二聚作用的植物gaga-factors在细胞核和核仁.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
alanine zipper-like coiled-coil domains are necessary for homotypic dimerization of plant gaga-factors in the nucleus and nucleolus丙氨酸zipper-like卷曲螺旋域所需的同型的二聚作用的植物gaga-factors在细胞核和核仁
Alanine Zipper-Like Coiled-Coil Domains Are Necessary
for Homotypic Dimerization of Plant GAGA-Factors in the
Nucleus and Nucleolus
Dierk Wanke*., Mareike L. Hohenstatt.¤, Marek Dynowski., Ulrich Bloss, Andreas Hecker, Kirstin Elgass,
Sabine Hummel, Achim Hahn, Katharina Caesar, Frank Schleifenbaum, Klaus Harter, Kenneth W.
Berendzen
¨ ¨
Center of Plant Molecular Biology (ZMBP) Plant Physiology, University of Tubingen, Tubingen, Germany
Abstract
GAGA-motif binding proteins control transcriptional activation or repression of homeotic genes. Interestingly, there are no
sequence similarities between animal and plant proteins. Plant BBR/BPC-proteins can be classified into two distinct groups:
Previous studies have elaborated on group I members only and so little is known about group II proteins. Here, we focused
on the initial characterization of AtBPC6, a group II protein from Arabidopsis thaliana. Comparison of orthologous BBR/BPC
sequences disclosed two conserved signatures besides the DNA binding domain. A first peptide signature is essential and
sufficient to target AtBPC6-GFP to the nucleus and nucleolus. A second domain is predicted to form a zipper-like coiled-coil
structure. This novel type of domain is similar to Leucine zippers, but contains invariant alanine residues with a heptad
spacing of 7 amino acids. By yeast-2-hybrid and BiFC-assays we could show that this Alanine zipper domain is essential for
homotypic dimerization of group II proteins in vivo. Interhelical salt bridges and charge-stabilized hydrogen bonds between
acidic and basic residues of the two monomers are predicted to form an interaction domain, which does not follow the
classical knobs-into-holes zipper model. FRET-FLIM analysis of GFP/RFP-hybrid fusion proteins validates the formation of
parallel d
您可能关注的文档
- activation of regulatory t cells during inflammatory response is not an exclusive property of stem cells调节性t细胞在炎症反应的激活不是干细胞的独家财产.pdf
- activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells可溶性的激活腺苷酸环化酶防止促分泌素刺激发酵菌激活大鼠pancreaic腺泡的细胞.pdf
- activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo需要展开的蛋白质反应的激活防御细菌造孔毒素在体内.pdf
- activation of thiazide-sensitive co-transport by angiotensin ii in the cyp1a1-ren2 hypertensive rat血管紧张素ⅱ的激活thiazide-sensitive co-transport cyp1a1-ren2高血压老鼠.pdf
- activation of the alternative nfκb pathway improves disease symptoms in a model of sjogren's syndrome激活的替代nfκb途径改善疾病症状干燥综合征的典范.pdf
- activation of the dormant secondary metabolite production by introducing gentamicin-resistance in a marine-derived penicillium purpurogenum g59激活休眠的次生代谢物生产中通过引入gentamicin-resistance marine-derived青霉菌purpurogenum g59.pdf
- activation of type iii interferon genes by pathogenic bacteria in infected epithelial cells and mouse placentaiii型干扰素基因的激活病原菌感染上皮细胞和小鼠胎盘.pdf
- activation-induced cytidine deaminase expression in cd4+ t cells is associated with a unique il-10-producing subset that increases with ageactivation-induced胞嘧啶核苷脱氨酶表达cd4 + t细胞与一个独特的il-10-producing子集,随着年龄的增加.pdf
- active and passive immunization protects against lethal, extreme drug resistant-acinetobacter baumannii infection主动和被动免疫预防致命,极端药物resistant-acinetobacter baumannii感染.pdf
- active collisions in altered gravity reveal eye-hand coordination strategies活跃的碰撞改变重力揭示手眼协调能力的策略.pdf
- alcohol consumption and oxidative dna damage饮酒和dna氧化损伤.pdf
- alcohol dehydrogenation with a dual site ruthenium, boron catalyst occurs at ruthenium酒精脱氢有双重网站钌硼发生在钌催化剂.pdf
- alcohol dependence associated with increased utilitarian moral judgment a case control study酒精依赖与功利主义的道德判断增加有关病例对照研究.pdf
- alcohol mixed with energy drinks consumption patterns and motivations for use in u.s. college students酒精混合能量饮料的消费模式和动机在美国大学生中使用.pdf
- alcohol taxes and birth outcomes酒精税和出生的结果.pdf
- albumin-like protein is the major protein constituent of luminal fluid in the human endolymphatic sacalbumin-like蛋白质的主要蛋白质成分在人类内淋巴的囊腔的流体.pdf
- alcohol use disorders (aud) among tuberculosis patients a study from chennai, south india酒精使用障碍(aud)肺结核患者的一项研究钦奈,印度南部.pdf
- alcohol-induced blackout饮酒导致的停电.pdf
- alcohol trajectories over three years in a swedish residence hall student population酒精在三年内轨迹在瑞典学生宿舍学生人口.pdf
- alcoholic pancreatitis pathogenesis, incidence and treatment with special reference to the associated pain酒精性胰腺炎发病机理、发病率和治疗有特殊引用相关的疼痛.pdf
文档评论（0）