有哪些信誉好的足球投注网站activation of src mediates pdgf-induced smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis激活src介导pdgf-induced smad1磷酸化和贡献在肾小球肾炎肾小球硬化症的恶化.pdfVIP
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activation of src mediates pdgf-induced smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis激活src介导pdgf-induced smad1磷酸化和贡献在肾小球肾炎肾小球硬化症的恶化
Activation of Src Mediates PDGF-Induced Smad1
Phosphorylation and Contributes to the Progression of
Glomerulosclerosis in Glomerulonephritis
1,3 1 1 2 3 3
Akira Mima , Hideharu Abe *, Kojiro Nagai , Hidenori Arai , Takeshi Matsubara , Makoto Araki ,
3 1 3 3 4 1
Kazuo Torikoshi , Tatsuya Tominaga , Noriyuki Iehara , Atsushi Fukatsu , Toru Kita , Toshio Doi
1 Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan, 2 Department of Geriatric Medicine, Kyoto
University Graduate School of Medicine, Kyoto, Japan, 3 Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 4 Department of
Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Abstract
Platelet-derived growth factor (PDGF) plays critical roles in mesangial cell (MC) proliferation in mesangial proliferative
glomerulonephritis. We showed previously that Smad1 contributes to PDGF-dependent proliferation of MCs, but the
mechanism by which Smad1 is activated by PDGF is not precisely known. Here we examined the role of c-Src tyrosine kinase
in the proliferative change of MCs. Experimental mesangial proliferative glomerulonephritis (Thy1 GN) was induced by a
single intravenous injection of anti-rat Thy-1.1 monoclonal antibody. In Thy1 GN, MC proliferation and type IV collagen
(Col4) expression peaked on day 6. Immunohistochemical staining for the expression of phospho-Src (pSrc), phospho-
Smad1 (pSmad1), Col4, and smooth muscle a-actin (SMA) revealed that the ac
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