有哪些信誉好的足球投注网站acute effect of ghrelin on ischemiareperfusion injury in the rat spinal cord急性胃促生长素对ischemiareperfusion损伤大鼠脊髓.pdfVIP
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acute effect of ghrelin on ischemiareperfusion injury in the rat spinal cord急性胃促生长素对ischemiareperfusion损伤大鼠脊髓
Int. J. Mol. Sci. 2012, 13, 9864-9876; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Acute Effect of Ghrelin on Ischemia/Reperfusion Injury in the
Rat Spinal Cord
Qin Zhang 1,2,†, Chen Huang 2,†, Bin Meng 2, Tiansi Tang 2, Qin Shi 2 and Huilin Yang 2,*
1 Department of Orthopedics, Yuncheng Central Hospital, Yuncheng 044000, China;
E-Mail: qinzhang_ 1976@163.com
2 Department of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow 215007,
China; E-Mails: huangchen131@ (C.H.); binmeng_yang@126.com (B.M.);
tiansitang19762@126.com (T.T.); shishiqinqin@ (Q.S.)
† These authors contributed equally to this work.
* Author to whom correspondence should be addressed; E-Mail: huilinyang@;
Tel.: +86-512-6778-1169; Fax: +86-512-6778-0999.
Received: 18 May 2012; in revised form: 17 July 2012 / Accepted: 19 July 2012 /
Published: 8 August 2012
Abstract: Ghrelin, a 28-amino acid peptide, is mainly secreted by the stomach. Ghrelin has
been shown to have neuroprotective effects. However, whether ghrelin protects the spinal
cord from ischemia/reperfusion (I/R) injury is unknown. To investigate this, 60 rats were
randomly divided into three different groups: the sham group (n = 20), the vehicle group
(n = 20), and the Ghrelin group (100 µg/kg, n = 20). Rats were sacrificed 12, 24, 48 and
72 h after ischemia. After the evaluation of neurologic function (48
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