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a submarine journey the pyrrole-imidazole alkaloidspyrrole-imidazole生物碱的海底之旅
Mar. Drugs 2009, 7, 705-753; doi:10.3390/md7040705
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Review
A Submarine Journey: The Pyrrole-Imidazole Alkaloids †
1 2 1 2
Barbara Forte , Beatrice Malgesini , Claudia Piutti , Francesca Quartieri , Alessandra
Scolaro 1 and Gianluca Papeo 1,*
1 Department of Medicinal Chemistry, Nerviano Medical Sciences, Viale Pasteur 10, 20014
Nerviano, Milano, Italy; E-Mails: barbara.forte@ (B.F.);
claudia.piutti@ (C.P.); alessandra.scolaro@ (A.S.)
2 Department of Chemical Core Technologies, Nerviano Medical Sciences, Viale Pasteur 10, 20014
Nerviano, Milano, Italy; E-Mails: beatrice.malgesini@ (B.M.);
francesca.quartieri@ (F.Q.)
†
Dedicated to our colleague and friend Dr. Sergio Mantegani, in recognition of his merits in natural
products chemistry, and in appreciation of his relentless endeavor to teach, advise and share his
chemistry skills in our organization.
* Author to whom correspondence should be addressed; E-Mail: gianluca.papeo@;
Tel.: +39-0331-58-1537; Fax: +39-0331-58-1347.
Received: 30 October 2009; in revised form: 20 November 2009 / Accepted: 26 November 2009 /
Published: 27 November 2009
Abstract: In his most celebrated tale “The Picture of Dorian Gray”, Oscar Wilde stated
that “those who go beneath the surface do so at their peril”. This sentence could be a
prophetical warning for the practitioner who voluntarily challenges himself with trying to
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