有哪些信誉好的足球投注网站a randomized trial evaluating prosaptide？ for hiv-associated sensory neuropathies use of an electronic diary to record neuropathic pain艾滋病毒相关的随机试验评估prosaptide 感觉神经病变的使用电子日记来记录神经性疼痛.pdfVIP
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a randomized trial evaluating prosaptide？ for hiv-associated sensory neuropathies use of an electronic diary to record neuropathic pain艾滋病毒相关的随机试验评估prosaptide 感觉神经病变的使用电子日记来记录神经性疼痛
A Randomized Trial Evaluating ProsaptideTM for
HIV-Associated Sensory Neuropathies: Use of an
Electronic Diary to Record Neuropathic Pain
1 2 1 3 4 5 3
Scott R. Evans *, David M. Simpson , Douglas W. Kitch , Agnes King , David B. Clifford , Bruce A. Cohen , Justin C. McArthur , for the
Neurologic AIDS Research Consortium and the AIDS Clinical Trials Group
1 Harvard School of Public Health, Boston, Massachusetts, United States of America, 2 Mount Sinai School of Medicine, New York, New York, United
States of America, 3 Johns Hopkins University, Baltimore, Maryland, United States of America, 4 Washington University, St. Louis, Missouri, United
States of America, 5 Northwestern University, Chicago, Illinois, United States of America
Objectives. To examine the efficacy and safety of ProsaptideTM (PRO) for the treatment of painful HIV-associated sensory
neuropathies (HIV-SN). Design. A randomized, double-blind, placebo-controlled, multicenter study in participants with
sensory neuropathy. Pain modulating therapy was discontinued prior to baseline. Participants were stratified by sural sensory
nerve action potential (SNAP) amplitude. Participants were trained to use an electronic diary (ED) to record pain. Setting.
Peripheral neuropathies are common complications of HIV infection. The pathogenesis is unknown and currently treatments
are restricted to symptomatic measures. We examined PRO against placebo (PBO) for treatment of painful HIV-SN and
performed a post-hoc evaluation of an electronic diary (ED) to record HIV-associated neuropathic pain. Participants. Eligible
participants included adults with neurologist-confirmed painful HIV-SN. Interventions. 2, 4, 8, or 16 mg/d
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