有哪些信誉好的足球投注网站a randomly-controlled study on the cardiac function at the early stage of return to the plains after short-term exposure to high altituderandomly-controlled研究的早期阶段的心脏功能返回平原后短期暴露于高海拔.pdfVIP
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a randomly-controlled study on the cardiac function at the early stage of return to the plains after short-term exposure to high altituderandomly-controlled研究的早期阶段的心脏功能返回平原后短期暴露于高海拔
A Randomly-Controlled Study on the Cardiac Function at
the Early Stage of Return to the Plains after Short-Term
Exposure to High Altitude
1,2 3 1,2 3 3 4 1,2
Qiquan Zhou *, Shengyue Yang , Yongjun Luo , Yushu Qi , Ziqiang Yan , Zifu Shi , Yong Fan
1 Department of High Altitude Diseases, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, China, 2 Key Laboratory of High Altitude
Medicine of Ministry of Education, Key Laboratory of High Altitude Medicine of PLA, Chongqing, China, 3 Respiratory Medicine Center of Lanzhou Military Command,
Fourth Hospital of PLA, Xining, China, 4 The 68303 Troop Hospital of People’s Liberation Army, Wuwei, China
Abstract
High altitude acclimatization and adaptation mechanisms have been well clarified, however, high altitude de-adaptation
mechanism remains unclear. In this study, we conducted a controlled study on cardiac functions in 96 healthy young male
who rapidly entered the high altitude (3700 m) and returned to the plains (1500 m) after 50 days. Ninety eight healthy male
who remained at low altitude were recruited as control group. The mean pulmonary arterial pressure (mPAP), left ventricular
ejection fraction (LVEF), left ventricular fraction shortening (LVFS), cardiac function index (Tei index) were tested. Levels of
serum creatine kinase isoform MB (CK-MB), lactate dehydrogenase isoenzyme-1 (LDH-1), endothelin-1 (ET-1), nitrogen oxide
(NO), serum hypoxia-inducible factor-1a (HIF-1a), 8-iso-prostaglandin F2a (8-iso PGF2a), superoxide dismutase (SOD) and
malonaldehyde (MDA) were measured at an altitude of 3700 m and 1500 m respectively. The results showed that after
short-term exposure to
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