a rapid change in virulence gene expression during the transition from the intestinal lumen into tissue promotes systemic dissemination of salmonella迅速改变肠道流明的毒性基因表达在过渡到组织中促进系统性传播沙门氏菌.pdfVIP

A Rapid Change in Virulence Gene Expression during the Transition from the Intestinal Lumen into Tissue Promotes Systemic Dissemination of Salmonella 1,2 1 1 3 ¨ 2,4 Sebastian E. Winter , Maria G. Winter , Ivan Godinez , Hee-Jeong Yang , Holger Russmann , Helene L. 3 ¨ 1 Andrews-Polymenis , Andreas J. Baumler * 1 Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America, 2 Max von ¨ ¨ ¨ ¨ Pettenkofer-Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universitat Munchen, Munchen, Germany, 3 Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas AM University System Health Science Center, College Station, Texas, United States of America, 4 HELIOS Klinikum Emil von ¨ Behring, Institut fur Mikrobiologie, Immunologie und Laboratoriumsmedizin, Berlin, Germany Abstract Bacterial pathogens causing systemic disease commonly evolve from organisms associated with localized infections but differ from their close relatives in their ability to overcome mucosal barriers by mechanisms that remain incompletely understood. Here we investigated whether acquisition of a regulatory gene, tviA, contributed to the ability of Salmonella enterica serotype Typhi to disseminate from the intestine to systemic sites of infection during typhoid fever. To study the consequences of acquiring a new regulator by horizontal gene transfer, tviA was introduced into the chromosome of S.