a randomized trial to assess anti-hiv activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel一个随机试验来评估抗艾滋病活动在女性生殖道分泌物和可溶性粘膜免疫的应用替诺福韦凝胶1%.pdfVIP
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a randomized trial to assess anti-hiv activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel一个随机试验来评估抗艾滋病活动在女性生殖道分泌物和可溶性粘膜免疫的应用替诺福韦凝胶1%
A Randomized Trial to Assess Anti-HIV Activity in Female
Genital Tract Secretions and Soluble Mucosal Immunity
Following Application of 1% Tenofovir Gel
1,2 . 3. 3 4 3
Marla J. Keller * , Rebecca P. Madan , N. Merna Torres , Melissa J. Fazzari , Sylvia Cho , Sabah
3 3 5 6 6
Kalyoussef , Gail Shust , Pedro M. M. Mesquita , Nicolette Louissaint , Jianmeng Chen , Hillel W.
4 1 1 7 6 2,3,5
Cohen , Erin C. Diament , Anna C. Lee , Lydia Soto-Torres , Craig W. Hendrix , Betsy C. Herold
1 Department of Medicine, Albert Einstein College of Medicine, New York, New York, United States of America, 2 Department of Obstetrics and Gynecology and Women’s
Health, Albert Einstein College of Medicine, New York, New York, United States of America, 3 Department of Pediatrics, Albert Einstein College of Medicine, New York, New
York, United States of America, 4 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, United States of America,
5 Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, United States of America, 6 Department of Medicine (Clinical
Pharmacology), Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 7 Division of AIDS, National Institute of Allergy and Infectious
Disease, National Institutes of Health, Bethesda, Maryland, United States of America
Abstract
Background: Preclinical and early phase clinical microbicide studies have not consistently predicted the outcome of e
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