有哪些信誉好的足球投注网站a randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women随机对照试验的试验阿奇霉素或青蒿琥酯添加到磺胺多辛-乙胺嘧啶在孕妇治疗疟疾.pdfVIP
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a randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women随机对照试验的试验阿奇霉素或青蒿琥酯添加到磺胺多辛-乙胺嘧啶在孕妇治疗疟疾
A Randomized Controlled Pilot Trial of Azithromycin or
Artesunate Added to Sulfadoxine-Pyrimethamine as
Treatment for Malaria in Pregnant Women
1 2 2 3 1 1 1
Linda Kalilani *, Innocent Mofolo , Marjorie Chaponda , Stephen J. Rogerson , Alisa P. Alker , Jesse J. Kwiek , Steven R. Meshnick
1 Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, 2 College of Medicine, University of
Malawi, Blantyre, Malawi, 3 University of Melbourne, Parkville, Australia
Objective. New anti-malarial regimens are urgently needed in sub-Saharan Africa because of the increase in drug resistance.
We investigated the safety and efficacy of azithromycin or artesunate combined with sulfadoxine-pyrimethamine used for
treatment of malaria in pregnant women in Blantyre, Malawi. Methods/Findings. This was a randomized open-label clinical
trial, conducted at two rural health centers in Blantyre district, Malawi. A total of 141 pregnant women with uncomplicated
Plasmodium falciparum malaria were recruited and randomly allocated to 3 treatment groups: sulfadoxine-pyrimethamine (SP;
3 tablets, 500 mg sulfadoxine and 25 mg pyrimethamine per tablet); SP plus azithromycin (1 g/day 62 days); or SP plus
artesunate (200 mg/day 63 days). Women received two doses administered at least 4 weeks apart. Heteroduplex tracking
assays were performed to distinguish recrudescence from new infections. Main outcome measures were incidence of adverse
outcomes, parasite and fever clearance times and recrudescence rates. All treatment regimens were well tolerated. Two
women vomited soon after ingesting azithromycin. The parasite clearance time was significantly faster in the SP-artesunate
group. Recrudescent episodes of malaria were less frequent with
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