功能区低级别胶质瘤患者生存影响因素分析.pdfVIP

安 黴 医 学 第 3 8 卷第 3 期 294 Anhui Medical Journal 2017年 3 月 功能区低级别胶质瘤患者生存影响因素分析 李 超 洪 文 清 吴 炳 山 陈 为 为 张 昊 张 敏 张 毛 松 张 晓 东 [摘要]目的探讨功能区低级别胶质瘤（LGGs )患者生存影响因素。方法回顾性分析2011年 1月至2015年6 月安黴 医科大学第一附属医院神经外科新诊断的62例功能区LGGs患者的临床资料，统计分析患者生存影响因素。结果单因素分析发 现年龄40岁、术前 KPS多70分、肿瘤全切、少突胶质细胞瘤、术后进行联合放化疗的功能区LGGs患者无进展生存期（PFS )和总生 存期（0S )优于年龄40岁、术前KPS 70分、非全切、星形细胞瘤或混合性少突-星形细胞瘤、术后不放化疗或单独放疗/化疗患 者，差异有统计学意义(P 〇.〇5);多因素分析示年龄、术前 KPS评分、手术切除程度、病理类型是影响生存的独立因素 （P 0.05)。 结论年龄较轻、术前高KPS评分及含有少突胶质细胞成分的功能区LGGs患者预后较佳，手术全切及术后放化疗能延长患者生 存期。 [关键词]胶质瘤;低级别;脑功能区;预后 doi ：10. 3969/j . issn . 1000-0399. 2017. 03. 009 Analysis of prognostic factors for survival in low - grade gliomas harboring eloquent areas LI Chao, HONG Wenqing ,W U Bingshan ,et al Department o f Neurosurgery, the First Affiliated Hospital o f Anhui Medical University, Hefei 23QQ22 ’China [ Abstract ] Objective To investigate the prognostic factors for survival in patients who had low grade gliomas harboring brain elo­ quent areas. Methods In this 5 years of study,62 cases newly diagnosed as low grade gliomas harboring eloquent areas were retro - analyzed to seek prognostic factors affecting survival. Firstly, Kaplan - meier method was applied to analyze 11 related clinical factors such as age, gen­ der, initial symptom, histological subtype, and so on. Then Cox multivariate regression analysis was used. Results Univariate analysis showed that patients with age 40 years, preoperative K P S ^ 70 points, total tumor resection, oligodendroglioma and postoperative chemo­ therapy combined with radiotherapy had longer progression - free survival ( PFS) and overall survival ( OS) thanthose patients whose age ^ 4 0 ye