壮药骨痹方烫疗对兔膝关节骨性关节炎NO、iNOS含量影响实验得研究.pdf

time 15 minutes, daily one time. The continual four weeks, Then to kill the rabbits. First roughly the visual observation each group of domestic rabbit articular cartilage surface situation and determine the content of Nitric Oxide (NO) in the synovial fluids. In the same time to give the carilage and synovium tissue even slurry iNOS determining. Results : The experiment study showed in group B the degeneration of articular cartilage and the inflammation of synovium occurred in the knee joints of the rabbits , the contents of NO were apparently higher in the joint fluids, the contents of iNOS were higher delivered in cartilage and synovium tissues. The surface of cartilage was rough and chap, and bared with fibrin. The pathology change of the control group and the treated group were among the normal group and the model group. The change of NO in joint fluids had significant difference in the treated group and the control group (P0.05). The change of iNOS in the synovium tissues had significant difference in the treated group and the control group (P0.05). Conclusion: NO may play important roles in the developing process of KOA, The expression of iNOS is the direct reason for the hige level of NO in local joint. Because zhuang medicine gubifang hot medicated compress(HMC) can decrease the content of iNOS and NO in the joint cartilage, alleviate the inflammation of synovium. So as to achieve the therapeutic effect on OA. Key word: zhuang medicine gubifang hot medicated compress(HMC) ; Knee joint osseous arthritis; Chinese medicine treatment; Experimental study 4 引 言 骨性关节炎(Osteoarthritis , OA )，又称骨性关节病，增生性关 节炎等，多发于中老年人，好发于负重较大，活动较多的关节，膝关节 是OA 常见的发病部位之一，病变关节内软骨的退化及损害后关节内骨的 增生，变形，导致关节功能障碍，严重的甚