necator americanus and helminth co-infections further down-modulation of hookworm-specific type 1 immune responsesnecator也和蠕虫病毒的进一步down-modulation hookworm-specific 1型免疫反应.pdfVIP
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necator americanus and helminth co-infections further down-modulation of hookworm-specific type 1 immune responsesnecator也和蠕虫病毒的进一步down-modulation hookworm-specific 1型免疫反应
Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses 1,2 2,3 4 Stefan Michael Geiger *, Neal Douglas Edward Alexander , Ricardo Toshio Fujiwara , Simon 3 3 2 1 1,2 Brooker , Bonnie Cundill , David Joseph Diemert , Rodrigo Correa-Oliveira , Jeffrey Michael Bethony ´ ˜ 1 Centro de Pesquisas Rene Rachou, Fundac¸ao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil, 2 Department of Microbiology, Immunology and Tropical Medicine, Medical Center, The George Washington University, Washington, D.C., United States of America, 3 Department of Infectious and Tropical Diseases and Department for ˆ Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, 4 Departamento de Parasitologia, Instituto de Ciencias ´ Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Abstract Background: Helminth co-infection in humans is common in tropical regions of the world where transmission of soil- transmitted helminths such as Ascaris lumbricoides, Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale as well as other helminths such as Schistosoma mansoni often occur simultaneously. Methodology: We investigated whether co-infection with another helminth(s) altered the
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