mouse models of human autoimmune diseases essential tools that require the proper controls人类自身免疫性疾病小鼠模型需要适当的控制的基本工具.pdfVIP

Open access, freely available online Primer Mouse Models of Human Autoimmune Diseases: Essential Tools That Require the Proper Controls Laurence Morel utoimmune diseases affl ict a while avoiding self-destruction. A diseases in particular. In the past few large segment of the population failure of this mechanism results in decades, the mouse has become the Ain Western countries. Many autoimmune reactions that often lead of them have been described, and to clinical disease. In spite of massive Citation: Morel L (2004) Mouse models of human rheumatoid arthritis, type I diabetes research efforts, the mechanisms by autoimmune disease: essential tools that require the proper controls. PLoS Biol 2(8): e241. (also called insulin-dependent diabetes which autoimmune diseases develop mellitus), multiple sclerosis, and are not clearly understood. Genetic Copyright: © 2004 Laurence Morel. This is an open- access article distributed under the terms of the Cre- systemic lupus erythematosus (SLE) are predisposition as well as environmental ative Commons Attribution License, which permits among the most common. Although triggers plays a role, but the identity of unrestricted use, distribution, and reproduction in tremendous progress has been made these factors has been largely elusive. any medium, p