nect is next implementing the new drug combination therapy for trypanosoma brucei gambiense sleeping sicknessnect下实现新的药物组合治疗锥虫属brucei gambiense昏睡病.pdfVIP

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nect is next implementing the new drug combination therapy for trypanosoma brucei gambiense sleeping sicknessnect下实现新的药物组合治疗锥虫属brucei gambiense昏睡病.pdf

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nect is next implementing the new drug combination therapy for trypanosoma brucei gambiense sleeping sicknessnect下实现新的药物组合治疗锥虫属brucei gambiense昏睡病

Viewpoints NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness 1 2 3 4 3,5 Oliver Yun *, Gerardo Priotto , Jacqueline Tong , Laurence Flevaud , Franc¸ois Chappuis ´ ` ´ ` 1 Medecins Sans Frontieres/Doctors Without Borders, New York, New York, United States of America, 2 Epicentre, Paris, France, 3 Medecins Sans Frontieres, Geneva, ´ ` Switzerland, 4 Medecins Sans Frontieres, Barcelona, Spain, 5 Geneva University Hospitals, Geneva, Switzerland Introduction In April 2009, a new treatment option, Chagas disease (American trypanosomia- nifurtimox-eflornithine combination ther- sis), and shown to have varying efficacy Fatal if untreated, human African apy (NECT), was added to the WHO against HAT [8–10]. trypanosomiasis (HAT; sleeping sickness) Essential Medicines List (EML) for the From 2001 through 2004, Epicentre, afflicts an estimated 50,000–70,000 people treatment of second-stage T. b. gambiense the research and epidemiology arm of each year [1], all in sub-Saharan Africa, HAT [6]. NECT was added to the EML Me´decins Sans Frontie`res/Doctors With- with only a minority of cases (nearly based on the high efficacy and good out Borders (MSF), conducted two se- 12,000 in 2008) being reported [2]. H