motor-cortical interaction in gilles de la tourette syndrome运动皮质互动gilles de la图雷特综合症.pdfVIP

Motor-Cortical Interaction in Gilles de la Tourette Syndrome 1,2 1,2 1,2 ¨ 1,2 Stephanie Franzkowiak , Bettina Pollok *, Katja Biermann-Ruben , Martin Sudmeyer , Jennifer 1,2 ¨ 3 3 4 ¨ 3 1,2 Paszek , Gotz Thomalla , Melanie Jonas , Michael Orth , Alexander Munchau , Alfons Schnitzler 1 Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, University of Dusseldorf, Duesseldorf, Germany, 2 Department of Neurology, Medical Faculty, University of Dusseldorf, Dusseldorf, Germany, 3 Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 4 Department of Neurology, University Hospital Ulm, Ulm, Germany Abstract Background: In Gilles de la Tourette syndrome (GTS) increased activation of the primary motor cortex (M1) before and during movement execution followed by increased inhibition after movement termination was reported. The present study aimed at investigating, whether this activation pattern is due to altered functional interaction between motor cortical areas. Methodology/Principal Findings: 10 GTS-patients and 10 control subjects performed a self-paced finger movement task while neuromagnetic brain activity was recorded using Magnetoencephalography (MEG). Cerebro-cerebral coherence as a measure of functional interaction was calculated. During movement preparation and execution coherence between contralateral M1 and supplementary motor area (SMA) was significantly increased at beta-frequency in