mutation accumulation in a selfing population consequences of different mutation rates between selfers and outcrossers突变积累在自交的人口后果不同的变异率selfers和outcrossers之间.pdfVIP

Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers 1 2 1 3 4 Shin-Ichiro Nakayama *, Shoi Shi , Masaki Tateno , Masakazu Shimada , K. Ryo Takahasi 1 Nikko Botanical Gardens, Graduate School of Science, The University of Tokyo, Tokyo, Japan, 2 Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan, 3 Department of General Systems Studies, Graduate School of Arts and Science, The University of Tokyo, Tokyo, Japan, 4 Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan Abstract Currently existing theories predict that because deleterious mutations accumulate at a higher rate, selfing populations suffer from more intense genetic degradation relative to outcrossing populations. This prediction may not always be true when we consider a potential difference in deleterious mutation rate between selfers and outcrossers. By analyzing the evolutionary stability of selfing and outcrossing in an infinite population, we found that the genome-wide deleterious mutation rate would be lower in selfing than in outcrossing organisms. When this difference in mutation rate was included in simulations, we found that in a small population, mutations accumulated more slowly under selfing rather than outcrossing. This result suggests that under frequent and intense bottlenecks, a selfing population may have a lower risk of genetic extinction than an outcrossing population. Citation: Nakayama S-I, Shi S, Tateno M, Shimada M, Takahasi KR (2012) Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers. PLoS ONE 7(3): e33541. doi:10.1371/journal.pone