有哪些信誉好的足球投注网站muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease肌肉痉挛和神经病变在同种异体造血干细胞移植患者和移植物抗宿主病.pdfVIP
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muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease肌肉痉挛和神经病变在同种异体造血干细胞移植患者和移植物抗宿主病
Muscle Cramps and Neuropathies in Patients with Allogeneic Hematopoietic Stem Cell Transplantation and Graft-versus-Host Disease 1 2 1¤ 1 3 4 Peter D. Kraus , Daniel Wolff , Oliver Grauer , Klemens Angstwurm , Sven Jarius , Klaus P. Wandinger , 2 1 5 Ernst Holler , Wilhelm Schulte-Mattler , Ingo Kleiter * 1 Department of Neurology, University Medical Centre Regensburg, Regensburg, Germany, 2 Department of Hematology and Clinical Oncology, University Medical Centre Regensburg, Regensburg, Germany, 3 Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany, 4 Institute for ¨ Experimental Neuroimmunology, affiliated to Euroimmun, Lubeck, Germany, 5 Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany Abstract Objective: Graft-versus-host disease (GVHD) is an immune-mediated multisystemic disorder and the leading cause of morbidity after allogeneic hematopoietic stem cell transplantation. Peripheral nervous system manifestations of GVHD are rare but often disabling. Whereas immune-mediated neuropathies are an established feature of GVHD, muscle cramps are not well characterized. Methods: In a single-centre retrospective cohort we studied 27 patients (age 23 to 69 years) with GVHD (acute n = 6, chronic n = 21) who complained of symptoms suggestive of peripheral nervous system complications. Clinical, laboratory and neurophysiological findings were evaluated by descriptive statistics and regression analysis to detect factors associated with muscle cramps. Patient’
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