multisensory information facilitates reaction speed by enlarging activity difference between superior colliculus hemispheres in rats多种感觉的信息有利于反应速度扩大活动在老鼠上丘半球之间的区别.pdfVIP

Multisensory Information Facilitates Reaction Speed by Enlarging Activity Difference between Superior Colliculus Hemispheres in Rats 1,2 1 3,4 1,5 6,7 Junya Hirokawa , Osamu Sadakane , Shuzo Sakata , Miquel Bosch , Yoshio Sakurai , Tetsuo Yamamori1* 1 Division of Brain Biology, National Institute for Basic Biology, Okazaki, Japan, 2 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, 3 Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey, United States of America, 4 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom, 5 The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 6 Department of Psychology, Kyoto University, Kyoto, Japan, 7 Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan Abstract Animals can make faster behavioral responses to multisensory stimuli than to unisensory stimuli. The superior colliculus (SC), which receives multiple inputs from different sensory modalities, is considered to be involved in the initiation of motor responses. However, the mechanism by which multisensory information facilitates motor responses is not yet understood. Here, we demonstrate that multisensory information modulates competition among SC neurons to elicit faster responses. We conducted multiunit recordings from the SC of rats performing a two-alternative spatial discrimination task using auditory and/or visual stimu