identification of chromatin-associated regulators of msl complex targeting in drosophila dosage compensation识别chromatin-associated监管机构在果蝇实验室复杂的目标剂量补偿.pdfVIP

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identification of chromatin-associated regulators of msl complex targeting in drosophila dosage compensation识别chromatin-associated监管机构在果蝇实验室复杂的目标剂量补偿.pdf

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identification of chromatin-associated regulators of msl complex targeting in drosophila dosage compensation识别chromatin-associated监管机构在果蝇实验室复杂的目标剂量补偿

Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation 1 1 2,3¤a 2¤b 4 Erica Larschan , Marcela M. L. Soruco , Ok-Kyung Lee , Shouyong Peng , Eric Bishop , 1 1 1 2,4 2,3 Jessica Chery , Karen Goebel , Jessica Feng , Peter J. Park , Mitzi I. Kuroda * 1 Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island, United States of America, 2 Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 3 Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Sex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the single male X approximately two-fold to equal the gene expression in females, which have two X-chromosomes. Dosage compensation is mediated by the Male-Specific Lethal (MSL) histone acetyltransferase complex. Five core components of the MSL complex were identified by genetic screens for genes that are specifically required for male viability and are dispensable for females. However, because dosage compensation must interface with the general transcriptional machinery, it is likely that identif