identification of continuous human b-cell epitopes in the envelope glycoprotein of dengue virus type 3 (denv-3)连续的识别人类b细胞抗原表位的登革病毒包膜糖蛋白3型(denv-3).pdfVIP

Identification of Continuous Human B-Cell Epitopes in the Envelope Glycoprotein of Dengue Virus Type 3 (DENV-3) ´ 1 4 ´ 1,3 Andrea N. M. Rangel da Silva , Eduardo J. M. Nascimento , Marli Tenorio Cordeiro , Laura H. V. G. Gil, 2{ 2 1,4,5 Frederico G. C. Abath , Silvia M. L. Montenegro , Ernesto T. A. Marques, Jr. * ˜ ˜ 1Virology and Experimental Therapy Laboratory, Aggeu Magalhaes Research Center, Fiocruz, Recife, Pernambuco, Brazil, 2 Department of Immunology, Aggeu Magalhaes ´ Research Center, Fiocruz, Recife, Pernambuco, Brazil, 3 Central Laboratory of Public Health, Secretaria de Saude do Estado de Pernambuco, Brazil, 4 The Johns Hopkins School of Medicine, Department of Medicine, Division of Infectious Diseases, Baltimore, Maryland, United States of America, 5 Department of Pharmacology and Molecular Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America Abstract Background: Dengue virus infection is a growing global public health concern in tropical and subtropical regions of the world. Dengue vaccine development has been hampered by concerns that cross-reactive immunological memory elicited by a candidate vaccine could increase the risk of development of more severe clinical forms. One possible strategy to reduce risks associated with a dengue vaccine is the development of a v