有哪些信誉好的足球投注网站multiple pathway-based genetic variations associated with tobacco related multiple primary neoplasms多个pathway-based基因变异与烟草相关的多个主要的肿瘤.pdfVIP
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multiple pathway-based genetic variations associated with tobacco related multiple primary neoplasms多个pathway-based基因变异与烟草相关的多个主要的肿瘤
Multiple Pathway-Based Genetic Variations Associated with Tobacco Related Multiple Primary Neoplasms 1¤ 2 1 1 3 Ashwin Kotnis , Junghyun Namkung , Sadhana Kannan , Nallala Jayakrupakar , Taesung Park , Rajiv 1 1 Sarin *, Rita Mulherkar * 1 Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India, 2 Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America, 3 Department of Statistics, College of Natural Science, Seoul National University, Seoul, Korea Abstract Background: In order to elucidate a combination of genetic alterations that drive tobacco carcinogenesis we have explored a unique model system and analytical method for an unbiased qualitative and quantitative assessment of gene-gene and gene-environment interactions. The objective of this case control study was to assess genetic predisposition in a biologically enriched clinical model system of tobacco related cancers (TRC), occurring as Multiple Primary Neoplasms (MPN). Methods: Genotyping of 21 candidate Single Nucleotide Polymorphisms (SNP) from major metabolic pathways was performed in a cohort of 151 MPN cases and 210 cancer-free controls. Statistical analysis using logistic regression and Multifactor Dimensionality Reduction (MDR) analysis was performed for studying higher order interactions among various SNPs and tobacco habit. Results: Increased risk association was observed for patients with at least one TRC in the upper aero digestive tract (UADT) for variations in SULT1A1 Arg213His, mEH Tyr113His, hOGG1 Ser326Cys, XRCC1 Arg280His and
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