motor decline in clinically presymptomatic spinocerebellar ataxia type 2 gene carriers电动机下降发生前症状临床上脊髓小脑的共济失调2型基因携带者.pdfVIP

Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers ´ 1 ´ 2 ´ ´ 1 1 ´ Luis Velazquez-Perez , Rosalinda Dıaz , Ruth Perez-Gonzalez , Nalia Canales , Roberto Rodrıguez- 1 ´ 1 ´ 1 1 1 Labrada , Jacquelın Medrano , Gilberto Sanchez , Luis Almaguer-Mederos , Cira Torres , Juan Fernandez-Ruiz2,3* ´ ´ ´ ´ ´ 1 Centro para la Investigacion y Rehabilitacion de las Ataxias Hereditarias, Holguın, Cuba, 2 Laboratorio de Neuropsicologıa, Departamento de Fisiologıa, Facultad de ´ ´ ´ ´ ´ Medicina, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Distrito Federal, Mexico, 3 Facultad de Psicologıa, Universidad Veracruzana, Xalapa, Veracruzana, ´ Mexico Abstract Background: Motor deficits are a critical component of the clinical characteristics of patients with spinocerebellar ataxia type 2. However, there is no current information on the preclinical manifestation of those motor deficits in presymptomatic gene carriers. To further understand and characterize the onset of the clinical manifestation in this disease, we tested presymptomatic spinocerebellar ataxia type 2 gene carriers, and volunteers, in a