有哪些信誉好的足球投注网站hydrogen peroxide stimulates activity and alters behavior in drosophila melanogaster过氧化氢促进活动和改变行为的黑腹果蝇.pdfVIP
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hydrogen peroxide stimulates activity and alters behavior in drosophila melanogaster过氧化氢促进活动和改变行为的黑腹果蝇
Hydrogen Peroxide Stimulates Activity and Alters Behavior in Drosophila melanogaster ¤ ´ Dhruv Grover , Daniel Ford, Christopher Brown, Nicholas Hoe, Aysen Erdem, Simon Tavare, John Tower* Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America Abstract Circadian rhythms in animals are regulated at the level of individual cells and by systemic signaling to coordinate the activities of multiple tissues. The circadian pacemakers have several physiological outputs, including daily locomotor rhythms. Several redox-active compounds have been found to function in regulation of circadian rhythms in cells, however, how particular compounds might be involved in regulating specific animal behaviors remains largely unknown. Here the effects of hydrogen peroxide on Drosophila movement were analyzed using a recently developed three-dimensional real- time multiple fly tracking assay. Both hydrogen peroxide feeding and direct injection of hydrogen peroxide caused increased adult fly locomotor activity. Continuous treatment with hydrogen peroxide also suppressed daily locomotor rhythms. Conditional over-expression of the hydrogen peroxide-producing enzyme superoxide dismutase (SOD) also increased fly activity and altered the patterns of locomotor activity across days and weeks. The real-time fly tracking system allowed for detailed analysis of the effects of these manipulations on behavior. For example, both hydrogen peroxide feeding and SOD over-expression increased all fly motion parameters, how
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