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hydrogen peroxide probes directed to different cellular compartments过氧化氢探针指向不同的细胞隔间
Hydrogen Peroxide Probes Directed to Different Cellular Compartments 1,2 3 4 5 1,2 Mikalai Malinouski , You Zhou , Vsevolod V. Belousov , Dolph L. Hatfield , Vadim N. Gladyshev * 1 Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska, United States of America, 2 Division of Genetics, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 3 Center for Biotechnology, University of Nebraska, Lincoln, Nebraska, United States of America, 4 Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, 5 Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America Abstract Background: Controlled generation and removal of hydrogen peroxide play important roles in cellular redox homeostasis and signaling. We used a hydrogen peroxide biosensor HyPer, targeted to different compartments, to examine these processes in mammalian cells. Principal Findings: Reversible responses were observed to various redox perturbations and signaling events. HyPer expressed in HEK 293 cells was found to sense low micromolar levels of hydrogen peroxide. When targeted to various cellular compartments, HyPer occurred in the reduced state in the nucleus, cytosol, peroxisomes, mitochondrial intermembrane space and mitochondria
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