有哪些信誉好的足球投注网站human α2β1hi cd133+ve epithelial prostate stem cells express low levels of active androgen receptor人类α2β1hi cd133 + ve前列腺上皮干细胞雄激素受体表达低水平的活跃.pdfVIP
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humanα2β1hicd133veepithelialprostatestemcellsexpresslowlevelsofactiveandrogenreceptor人类α2β1hicd133ve前列腺上皮干细胞雄激素受体表达低水平的活跃
Human a b HI CD133+VE Epithelial Prostate Stem Cells 2 1 Express Low Levels of Active Androgen Receptor 1 1 1 1 1 Stuart C. Williamson , Anastasia C. Hepburn , Laura Wilson , Kelly Coffey , Claudia A. Ryan-Munden , 1 2 1 1 Deepali Pal , Hing Y. Leung , Craig N. Robson , Rakesh Heer * 1 Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, 2 The Beatson Institute for Cancer Research, Glasgow, East Dunbartonshire, United Kingdom Abstract Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated. One of the conflicts with this model is that cancer stem cells have been described to lack androgen receptor (AR) expression, which is of established importance in prostate cancer initiation and progression. We re-examined the expression patterns of AR within adult prostate epithelial differentiation using an optimised sensitive and specific approach examining transcript, protein and AR regulated gene expression. Highly enriched populations were isolated consisting of stem (a b HI CD133+VE), transiently amplifying (a b HI CD133–VE) and terminally differentiated (a b LOW 2 1 2 1 2 1 CD133–VE) cells. AR transcript and protein expression was confirmed in a b HI CD133+VE and CD133–VE progenitor cells. Flow
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