hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of parkinsons disease饮用水中氢减少多巴胺能神经元损失1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine帕金森病小鼠模型.pdfVIP

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hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of parkinsons disease饮用水中氢减少多巴胺能神经元损失1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine帕金森病小鼠模型.pdf

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hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of parkinsons disease饮用水中氢减少多巴胺能神经元损失1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine帕金森病小鼠模型

Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine Mouse Model of Parkinson’s Disease 1 1 2 2 2 2 Kyota Fujita , Toshihiro Seike , Noriko Yutsudo , Mizuki Ohno , Hidetaka Yamada , Hiroo Yamaguchi , 2 1 3 4 4 Kunihiko Sakumi , Yukiko Yamakawa , Mizuho A. Kido , Atsushi Takaki , Toshihiko Katafuchi , Yoshinori Tanaka5, Yusaku Nakabeppu2., Mami Noda1.* 1 Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, 2 Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 3 Department of Oral Anatomy and Cell Biology, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan, 4 Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 5 RD Center, Home Appliances Manufacturing Business Unit, Panasonic Electric Works Co., Ltd., Osaka, Japan Abstract It has been shown that molecular hydrogen (H ) acts as a therapeutic antioxidant and suppresses brain injury by buffering 2 the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson’s disease (PD). Here, we show that drinking H2-containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The concentration- dependency of H2 showed that H2 as low as 0.08 ppm had almost the