有哪些信誉好的足球投注网站hypoxia activated egfr signaling induces epithelial to mesenchymal transition (emt)缺氧活性表皮生长因子受体信号诱导上皮间充质转变(emt).pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
hypoxia activated egfr signaling induces epithelial to mesenchymal transition (emt)缺氧活性表皮生长因子受体信号诱导上皮间充质转变(emt)
Hypoxia Activated EGFR Signaling Induces Epithelial to Mesenchymal Transition (EMT) Ashish Misra.¤, Chhiti Pandey., Siu Kwan Sze*, Thirumaran Thanabalu* School of Biological Sciences, Nanyang Technological University, Singapore, Singapore Abstract Metastasis is a multi-step process which requires the conversion of polarized epithelial cells to mesenchymal cells, Epithelial–Mesenchymal Transition (EMT). EMT is essential during embryonic morphogenesis and has been implicated in the progression of primary tumors towards metastasis. Hypoxia is known to induce EMT; however the molecular mechanism is still poorly understood. Using the A431 epithelial cancer cell line, we show that cells grown under hypoxic conditions migrated faster than cells grown under normal oxygen environment. Cells grown under hypoxia showed reduced adhesion to the extracellular matrix (ECM) probably due to reduced number of Vinculin patches. Growth under hypoxic conditions also led to down regulation of E-cadherin and up regulation of vimentin expression. The increased motility of cells grown under hypoxia could be due to redistribution of Rac1 to the plasma membrane as opposed to increased expression of Rac1. EGF (Epidermal Growth Factor) is a known inducer of EMT and growth of A431 cells in the absence of oxygen led to increased expression of EGFR (EGF Receptor). Treatment of A431 cells with EGF led to reduced cell adhesion to ECM, increased cell motility and other EMT characteristics. Furthermore, this transition was blocked by the monoclonal antibody Cetuximab. Cetuximab also blocked the hypoxia-induced EMT suggesting that cell growth under hypoxic conditions led to activation of EGFR signaling and induction of EMT phenotype. Citation: Misra A, Pandey C, Sze SK, Thanabalu T (2012) Hypoxia Activated EGFR Signali
您可能关注的文档
- hiv-associated tb in an giang province, vietnam, 2001–2004 epidemiology and tb treatment outcomes江省艾滋病结核病,越南,2001 - 2004年结核病流行病学和治疗结果.pdf
- hiv-1 with multiple ccr5cxcr4 chimeric receptor use is predictive of immunological failure in infected childrenhiv - 1与多个ccr5cxcr4嵌合受体使用预测受感染儿童的免疫失败.pdf
- hiv-infected former plasma donors in rural central china from infection to survival outcomes, 1985–2008艾滋病毒感染前血浆捐献者在中国中部农村从感染到生存结果,1985 - 2008.pdf
- hiv-prevalence in tuberculosis patients in germany, 2002–2009 an estimation based on hiv and tuberculosis surveillance data肺结核患者的艾滋病毒感染率在德国,2002 - 2009年的估计基于艾滋病和结核病监测数据.pdf
- hiv-neutralizing activity of cationic polypeptides in cervicovaginal secretions of women in hiv-serodiscordant relationshipshiv-neutralizing cervicovaginal分泌物的活性阳离子多肽的女性一方有关系.pdf
- hla class i binding 9mer peptides from influenza a virus induce cd4+ t cell responses我绑定9 mer hla类肽从甲型流感病毒引起cd4 + t细胞反应.pdf
- hla alleles associated with slow progression to aids truly prefer to present hiv-1 p24hla等位基因与缓慢发展为艾滋病hiv - 1 p24真正喜欢礼物.pdf
- hla class i-t cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of cd8+ t cells in chronic chagas diseasehla类它揭示细胞抗原表位从trans-sialidase蛋白质功能不同子集的cd8 + t细胞在慢性恰加斯病.pdf
- hla class i restriction as a possible driving force for chikungunya evolutionhla类我限制作为一个可能的基孔肯雅热演化驱动力.pdf
- hla-a0206 with tlr3 polymorphisms exerts more than additive effects in stevens-johnson syndrome with severe ocular surface complicationshla-a0206 tlr3多态性施加超过添加剂影响表面在史蒂文斯u2014约翰逊综合征严重眼部并发症.pdf
- hypoxia changes the expression of the epidermal growth factor (egf) system in human hearts and cultured cardiomyocytes缺氧变化的表达表皮生长因子(egf)系统在人类心灵和培养的心肌细胞.pdf
- hypoxia enhances the proliferative response of macrophages to csf-1 and their pro-survival response to tnf缺氧增强巨噬细胞的增殖反应csf-1及其pro-survival应对tnf.pdf
- hypoxia increases mouse satellite cell clone proliferation maintaining both in vitro and in vivo heterogeneity and myogenic potential缺氧增加鼠标卫星细胞克隆增殖维持体外和体内的异质性和肌原性的潜力.pdf
- hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae缺氧抑制肥厚性分化和外植胫骨软骨内成骨.pdf
- hypoxia regulates cd44 and its variant isoforms through hif-1α in triple negative breast cancer通过hif-1α缺氧调节cd44及其变异亚型三阴性乳腺癌.pdf
- hypoxia responses how different cells and tumors react to oxygen shortage缺氧的反应不同的细胞和肿瘤如何应对氧气短缺.pdf
- hypoxia induces dilated cardiomyopathy in the chick embryo mechanism, intervention, and long-term consequences缺氧引起扩张型心肌病的小鸡胚胎机制,干预,和长期的后果.pdf
- hypoxia transiently sequesters mps1 and polo to collagenase-sensitive filaments in drosophila prometaphase oocytes缺氧是暂时性的扣押mps1和马球collagenase-sensitive丝果蝇前中期卵母细胞.pdf
- hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of runx2 by twist缺氧抑制骨在人类间充质干细胞通过直接调节runx2的转折.pdf
- hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the cx3cr1 gene低氧factor-1α调节趋化迁移胰腺导管腺癌的细胞通过直接transactivating cx3cr1基因.pdf
文档评论（0）