hiv-neutralizing activity of cationic polypeptides in cervicovaginal secretions of women in hiv-serodiscordant relationshipshiv-neutralizing cervicovaginal分泌物的活性阳离子多肽的女性一方有关系.pdfVIP

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hiv-neutralizing activity of cationic polypeptides in cervicovaginal secretions of women in hiv-serodiscordant relationshipshiv-neutralizing cervicovaginal分泌物的活性阳离子多肽的女性一方有关系.pdf

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hiv-neutralizing activity of cationic polypeptides in cervicovaginal secretions of women in hiv-serodiscordant relationshipshiv-neutralizing cervicovaginal分泌物的活性阳离子多肽的女性一方有关系

HIV-Neutralizing Activity of Cationic Polypeptides in Cervicovaginal Secretions of Women in HIV- Serodiscordant Relationships 1 2,3 4 1 1 2,3,5 Pauline Levinson , Robert Y. Choi , Amy L. Cole , Taha Hirbod , Samuel Rhedin , Barbara Payne , 6 2,7 4 3,5,6 1 Brandon L. Guthrie , Rose Bosire , Alexander M. Cole , Carey Farquhar , Kristina Broliden * 1 Unit of Infectious Diseases, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 2 Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya, 3 Department of Medicine, University of Washington, Seattle, Washington, United States of America, 4 Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America, 5 Department of Global Health, University of Washington, Seattle, Washington, United States of America, 6 Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, 7 Centre for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya Abstract Background: HIV exposed seronegative (HESN) women represent the population most in need of a prophylactic antiviral strategy. Mucosal cationic polypeptides can potentially be regulated for this purpose and we here aimed to determine their endogenous expression and HIV neutralizing activity in genital secretions of women at risk of HIV infection.