hypoxia transiently sequesters mps1 and polo to collagenase-sensitive filaments in drosophila prometaphase oocytes缺氧是暂时性的扣押mps1和马球collagenase-sensitive丝果蝇前中期卵母细胞.pdfVIP

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hypoxia transiently sequesters mps1 and polo to collagenase-sensitive filaments in drosophila prometaphase oocytes缺氧是暂时性的扣押mps1和马球collagenase-sensitive丝果蝇前中期卵母细胞.pdf

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hypoxia transiently sequesters mps1 and polo to collagenase-sensitive filaments in drosophila prometaphase oocytes缺氧是暂时性的扣押mps1和马球collagenase-sensitive丝果蝇前中期卵母细胞

Hypoxia Transiently Sequesters Mps1 and Polo to Collagenase-Sensitive Filaments in Drosophila Prometaphase Oocytes 1,2 1,3 1,4 1 1 William D. Gilliland *, Dana L. Vietti , Nicole M. Schweppe , Fengli Guo , Teri J. Johnson , R. Scott Hawley1,5,6 1 Stowers Institute for Medical Research, Kansas City, Missouri, United States of America, 2 Department of Biological Sciences, DePaul University, Chicago, Illinois, United States of America, 3 University of Kansas Medical Center, Kansas City, Kansas, United States of America, 4 Kansas City University of Medicine and Biosciences, Kansas City, Missouri, United States of America, 5 Department of Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America, 6 American Cancer Society Research Professor, Atlanta, Georgia, United States of America Abstract Background: The protein kinases Mps1 and Polo, which are required for proper cell cycle regulation in meiosis and mitosis, localize to numerous ooplasmic filaments during prometaphase in Drosophila oocytes. These filaments first appear throughout the oocyte at the end of prophase and are disassembled after egg activation. Methodology/Principal Findings: We showed here that Mps1 and Polo proteins undergo dynamic and reversible localization to static ooplasmic filaments as part of an oocyte-specific response to hypoxia. The observation that Mps1- and Polo-associated filaments reappear in the same locations through multiple cycles of oxygen deprivation demonstrates that underlying structural components of the filaments must still be present during normoxic conditions. Using immuno- electron microscopy, we observed trip