有哪些信誉好的足球投注网站hla-a0206 with tlr3 polymorphisms exerts more than additive effects in stevens-johnson syndrome with severe ocular surface complicationshla-a0206 tlr3多态性施加超过添加剂影响表面在史蒂文斯u2014约翰逊综合征严重眼部并发症.pdfVIP
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hla-a0206 with tlr3 polymorphisms exerts more than additive effects in stevens-johnson syndrome with severe ocular surface complicationshla-a0206 tlr3多态性施加超过添加剂影响表面在史蒂文斯u2014约翰逊综合征严重眼部并发症
HLA-A*0206 with TLR3 Polymorphisms Exerts More than Additive Effects in Stevens-Johnson Syndrome with Severe Ocular Surface Complications 1,2 3 1 3 4 1 Mayumi Ueta *, Katsushi Tokunaga , Chie Sotozono , Hiromi Sawai , Gen Tamiya , Tsutomu Inatomi , Shigeru Kinoshita1 1 Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 2 Research Center for Inflammation and Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan, 3 Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan, 4 Advanced Molecular Epidemiology Research Institute, Faculty of Medcine, Yamagata University, Yamagata, Japan Abstract Background: Stevens-Johnson syndrome (SJS) is an acute inflammatory vesiculobullous reaction of the skin and mucosa, often including the ocular surface, and toxic epidermal necrolysis (TEN) occurs with its progression. Although SJS/TEN is thought to be initiated by certain types of medication coupled with possible infection. In the present study we examined the multiplicative interaction(s) between HLA-A*0206 and 7 Toll-like receptor 3 (TLR3) Single-nucleotide polymorphisms (SNPs) in patients with SJS/TEN. Principal Findings: We analyzed the genotypes for HLA-A and 7 TLR3 SNPs in 110 Japanese SJS/TEN patients with severe ocular complications and 206 healthy volunteers to examine the interactions between the two loci. We found that HLA- A*0206 exhibited a high odds ratio for SJS/TEN (carrier frequency: OR = 5.1; gene frequency: OR = 4.0) and that there was a strong association with TLR3 rs.5743312T/T SNP (OR = 7.4), TLR3 rs.3775296T/T SNP (OR = 5.8), TLR3 rs.6822014G/G SNP (OR = 4.8), TLR3 rs.3775290A/A SNP (OR = 2.9), TLR3 rs.7
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