有哪些信誉好的足球投注网站hla class i-t cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of cd8+ t cells in chronic chagas diseasehla类它揭示细胞抗原表位从trans-sialidase蛋白质功能不同子集的cd8 + t细胞在慢性恰加斯病.pdfVIP
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hlaclassi-tcellepitopesfromtrans-sialidaseproteinsrevealfunctionallydistinctsubsetsofcd8tcellsinchronicchagasdiseasehla类它揭示细胞抗原表位从trans-sialidase蛋白质功能不同子集的cd8t细胞在慢性恰加斯病
HLA Class I-T Cell Epitopes from trans-Sialidase Proteins Reveal Functionally Distinct Subsets of CD8+ T Cells in Chronic Chagas Disease ´ 1 2 3 ´ 2 4 Marıa G. Alvarez , Miriam Postan , D. Brent Weatherly , Marıa C. Albareda , John Sidney , Alessandro 4 2 1 3. 2. Sette , Carina Olivera , Alejandro H. Armenti , Rick L. Tarleton , Susana A. Laucella * ´ ´ ´ ´ 1 Hospital Interzonal General de Agudos ‘‘Eva Peron’’, San Martın, Provincia de Buenos Aires, Argentina, 2 Instituto Nacional de Parasitologıa ‘‘Dr. Mario Fatala Chaben’’, Buenos Aires, Argentina, 3 Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America, 4 La Jolla Institute of Allergy and Immunology, La Jolla, California, United States of America Abstract Background: Previously, we identified a set of HLA-A020.1-restricted trans-sialidase peptides as targets of CD8+ T cell responses in HLA-A0201+ individuals chronically infected by T. cruzi. Methods and Findings: Herein, we report the identification of peptides encoded by the same trans-sialidase gene family that bind alleles representative of the 6 most common class I HLA-supertypes. Based on a combination of bioinformatic predictions and HLA-supertype considerations, a total of 1001 epitopes predicted to bind to HLA A01, A02, A03, A24
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