hypersensitivity in borderline personality disorder during mindreading过敏症在心智解读边缘型人格障碍.pdfVIP

Hypersensitivity in Borderline Personality Disorder during Mindreading 1. 1 . 2 1 1 Carina Frick , Simone Lang * , Boris Kotchoubey , Simkje Sieswerda , Ramona Dinu-Biringer , 1,3 2 3,4 1 Moritz Berger , Sandra Veser , Marco Essig , Sven Barnow 1 Department of Clinical Psychology and Psychotherapy, University of Heidelberg, Heidelberg, Germany, 2 Institute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Tuebingen, Germany, 3 German Cancer Research Center (DKFZ), Heidelberg, Germany, 4 Department of Neuroradiology, University of Erlangen, Erlangen, Germany Abstract Background: One of the core symptoms of borderline personality disorder (BPD) is the instability in interpersonal relationships. This might be related to existent differences in mindreading between BPD patients and healthy individuals. Methods: We examined the behavioural and neurophysiological (fMRI) responses of BPD patients and healthy controls (HC) during performance of the ‘Reading the Mind in the Eyes’ test (RMET). Results: Mental state discrimination was significantly better and faster for affective eye gazes in BPD patients than in HC. At the neurophysiological level, this was manifested in a stronger activation of the amygdala and greater activity of the medial frontal gyrus, the left temporal pole and the middle temporal gyrus during affective eye gazes. In contrast, HC subjects showed a greater activation in the insula and the superior temporal gyri. Conclusion: These findings indicate that BPD patients are highly vigilant to social stimuli, maybe because they resonate intuitive